After fleeing an East Tennessee brothel run by abusive pimp Crayven and his sister Marjorie, Dorothy Mae hitches a ride with lovable roadkill collector Randy Rankin, who accidentally manages to reunite Dorothy Mae with her best friend Simone. Simone vows to help Dorothy rescue Cray's remaining victims and the determined women hatch a plan - only to have it derailed by an unimaginable act of brutality.