![The Substance [Spanish]](https://pbcdnw.aoneroom.com/image/2026/01/26/ecb623a49694d5828a0bc49f683422b9.jpg)
A fading celebrity takes a black-market drug: a cell-replicating substance that creates a younger, better version of herself.
Trailer
Cast
Demi Moore
Elisabeth
Margaret Qualley
Sue
Dennis Quaid
Harvey
EH
Edward Hamilton-Clark
Fred
Gore Abrams
Oliver
Oscar Lesage
Troy
Christian Erickson
Man at Diner
Robin Greer
Male Nurse
Tom Morton
Doctor
Hugo Diego Garcia
Diego - Boyfriend
Daniel Knight
Casting Director
Jonathon Carley
Assistant Casting Director
Jiselle Henderkott
Girl Auditioning
Jiselle Henderkott
Dancer - New Year's Eve Show
Akil Wingate
TV Host
Billy Bentley
Man in Suit #1 - Harvey's Office
Vincent Colombe
Man in Suit #2
Lennard Ridsdale
Man in Suit #3
Jordan Ford Silver
Assistant Director - Pump It Up Show
Maaari Mo Ring Magustuhan
Katatakutan5.4
Year 10
Katatakutan2.4
Snake Hotel
Katatakutan3.1
Don't Speak
Drama4.5
Into the Abyss
Krimen8.1
Adolescence
Drama6.8
Fear the Walking Dead
Drama7.9
American Horror Story
Drama6.7
Cassandra
Drama7.2
Glitch
Drama8.3
The Originals
Krimen8.5
Snowfall
Aksyon7.8
The Witcher
Komedya6.6
XO, Kitty
Drama7.2
Glitch
Drama7.6
Best Interests
Krimen4.5
The Oval
Krimen5.0
Fatal Seduction
Drama7.8
From
Drama7.4
Empire
Drama7.3
The Summer I Turned Pretty
Krimen7.0
The Cleaning Lady
Drama7.5
Bridgerton
Aksyon9.1
Ithonga
Komedya5.6
Sex/Life
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🐺Dec 17, 2025