![The Substance [SpanishLatam]](https://pbcdnw.aoneroom.com/image/2026/01/26/ecb623a49694d5828a0bc49f683422b9.jpg)
A fading celebrity takes a black-market drug: a cell-replicating substance that creates a younger, better version of herself.
Trailer
Cast
Demi Moore
Elisabeth
Margaret Qualley
Sue
Dennis Quaid
Harvey
EH
Edward Hamilton-Clark
Fred
Gore Abrams
Oliver
Oscar Lesage
Troy
Christian Erickson
Man at Diner
Robin Greer
Male Nurse
Tom Morton
Doctor
Hugo Diego Garcia
Diego - Boyfriend
Daniel Knight
Casting Director
Jonathon Carley
Assistant Casting Director
Jiselle Henderkott
Girl Auditioning
Jiselle Henderkott
Dancer - New Year's Eve Show
Akil Wingate
TV Host
Billy Bentley
Man in Suit #1 - Harvey's Office
Vincent Colombe
Man in Suit #2
Lennard Ridsdale
Man in Suit #3
Jordan Ford Silver
Assistant Director - Pump It Up Show
Maaari Mo Ring Magustuhan
Drama7.2
The Substance
Katatakutan5.4
Year 10
Katatakutan2.4
Snake Hotel
Katatakutan3.1
Don't Speak
Krimen8.1
Adolescence
Drama6.8
Fear the Walking Dead
Drama7.9
American Horror Story
Drama6.7
Cassandra
Drama7.2
Glitch
Komedya5.7
Sistas
Drama7.6
All American
Drama8.6
Stranger Things
Drama8.3
The Originals
Drama7.2
Glitch
Katatakutan6.3
Teacup
Aksyon7.9
Into the Badlands
Aksyon7.8
The Witcher
Komedya7.5
Ginny & Georgia
Aksyon7.4
The Night Agent
Drama7.8
Adulting
Krimen4.8
Ruthless
Drama7.0
Siren
Aksyon9.1
Shaka iLembe
Drama7.3
The Summer I Turned Pretty
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kess rui🇲🇿Dec 17, 2025