Looking for the best Nonupeipe relics in Slay the Spire 2? In this tier list, I rank every Nonupeipe relic from S-Tier to bait tier and explain which relics are actually worth taking during your runs. Some of these relics can completely carry a run, while others are far more situational than they first appear. I break down the strongest relics, underrated picks, risky choices, and the relics that can help you climb Ascension more consistently in STS2. This Slay the Spire 2 tier list covers: - The best Nonupeipe relics - S-Tier relic rankings - Strong early and late game relics - Relics that win runs consistently - Overrated and underrated relics - Strategy and synergy discussion for STS2 If you enjoy Slay the Spire 2 guides, tier lists, gameplay, and strategy content, make sure to subscribe for more STS2 videos. 00:00 Intro 00:30 Disclaimer 00:44 Beautiful Bracelet 02:15 Blessed Antler 04:07 Brilliant Scarf 05:29 Delicate Frond 08:20 Diamond Diadem 10:08 Fur Coat 12:34 Glitter 14:43 Jewelry Box/Apotheosis 16:39 Looming Fruit 19:57 Signet Ring 22:17 Final Thoughts And check out my twitch link below. I stream Monday, Tuesday, Thursday, and Friday night at 9pm EST on twitch. https://www.twitch.tv/nerdyhickey https://www.twitter.com/rhickey28 https://www.tiktok.com/@nerdyhickey #slaythespire2 #slaythespire #roguelike #deckbuilder