Kothaga Maa Prayanam is about Karthik "Priyanth" who is a playboy and doesn't believe in marriage and love. He proposes Keerthi "Yamini Bhaskar", a new employee at his office to start a live in relationship. Keerthi, who also likes him agrees on the condition that he stops his playboy ways. Things go wrong between them when Keerthi catches him with another girl.