E Ee is about Siddhu (Neiraj Sham,) who hates women. Hasini (Naira Shah,) who detests men, joins Siddhu's company and trouble starts brewing, as the two don't get along. On a company trip, Siddhu and Hasini get into a heated argument and Siddhu insults all women. This is overheard by a Swami, who curses them both. Siddhu's and Hasini's souls are interchanged. Does this bring the two closer?