Jhon (Pepe Herrera), the human representation of bad luck, is sent by his narcissistic boss Nestor on his last delivery errand before flying to Malaysia. Jhon is resetting his life; he wants to start anew abroad. But as luck would have it, 223 (Arci Muñoz), a Martian runaway bride, takes off after him because she believes her spaceship is in his delivery box. She follows him to the airport, causing him to miss his flight to Malaysia. With his bad luck, Jhon thinks he has nothing left to lose. Together, they embark on a mission to look for the lost spaceship--for him to get rid of her and her to get rid of him--without knowing they will find love along the way. All these after 223 kisses Jhon on the lips, what they call in Mars Intergalactic Oral Transference or IOT.